Palmitoylcarnitine/Carnitine exchange

Contributor: Saverio Marchi
{"name":"Palmitoylcarnitine\/Carnitine exchange","theorem":{"head":{"_type":"conjunction","components":[{"_type":"molecule","name":"CARN","position":4},{"_type":"protein","name":"SLC25A20","position":2},{"_type":"molecule","name":"L-PCARN","position":1}]},"body":{"_type":"conjunction","components":[{"_type":"molecule","name":"CARN","position":1},{"_type":"protein","name":"SLC25A20","position":2},{"_type":"molecule","name":"L-PCARN","position":4}]}},"steps":[{"head":{"_type":"interaction","position":7,"components":[{"_type":"molecule","name":"CARN","position":1},{"_type":"protein","name":"SLC25A20","position":2},{"_type":"molecule","name":"L-PCARN","position":4}]},"body":{"_type":"conjunction","components":[{"_type":"molecule","name":"CARN","position":1},{"_type":"protein","name":"SLC25A20","position":2},{"_type":"molecule","name":"L-PCARN","position":4}]}},{"head":{"_type":"interaction","position":7,"components":[{"_type":"molecule","name":"CARN","position":4},{"_type":"protein","name":"SLC25A20","position":2},{"_type":"molecule","name":"L-PCARN","position":1}]},"body":{"_type":"interaction","position":7,"components":[{"_type":"molecule","name":"CARN","position":1},{"_type":"protein","name":"SLC25A20","position":2},{"_type":"molecule","name":"L-PCARN","position":4}]}},{"head":{"_type":"conjunction","components":[{"_type":"molecule","name":"CARN","position":4},{"_type":"protein","name":"SLC25A20","position":2},{"_type":"molecule","name":"L-PCARN","position":1}]},"body":{"_type":"interaction","position":7,"components":[{"_type":"molecule","name":"CARN","position":4},{"_type":"protein","name":"SLC25A20","position":2},{"_type":"molecule","name":"L-PCARN","position":1}]}}]}

Theorem

Information

The carnitine-acylcarnitine transporter (SLC25A20), located at the inner mitochondrial membrane, regulates the exchange of palmitoylcarnitine (L-PCARN), as well as other acylcarnitine esters, and carnitine. Inside the matrix, acylcarnitines are reconverted into carnitine and long-chain acyl-CoAs, which can be then oxidized by the fatty acid-oxidation pathway.

 

References:

Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F. The mitochondrial carnitine/acylcarnitine carrier:
function, structure and physiopathology. Mol Aspects Med. 2011 Aug;32(4-6):223-33. doi: 10.1016/j.mam.2011.10.008. Epub 2011 Oct 15. PMID:
22020112.

Ramsay RR, Gandour RD, van der Leij FR. Molecular enzymology of carnitine transfer and transport. Biochim Biophys Acta. 2001 Mar 9;1546(1):21-43. doi: 10.1016/s0167-4838(01)00147-9. PMID: 11257506.

 

Link to other Databases:

Reactome: https://reactome.org/content/detail/R-HSA-200424

Mitochondrial processes

Demonstrative and biological steps

Dynamic view

Mito-location

Not Available/Not Relevant
    M
    Matrix
      IM
      Inner Membrane
        IMS
        Inter-Membrane Space
          OM
          Outer Membrane
            PMS
            Peri-Mitochondrial Space

              Dynamic mito-location